Research in the lab is focused on protein structure and function. We apply biochemistry, X-ray crystallography and computational modeling to obtain a deep understanding of the relationship of protein structure and function. Though numerous phosphorylation-dependent signaling pathways are modulated by redox signaling, the limited availability of structures of the phosphorylated proteins, kinase-substrate complexes and redox-modified proteins prevent an in-depth understanding of the mechanisms involved in redox regulation of many kinase-substrate pairs. Research in Dong Lab is focused on understanding the mechanisms underlying redox regulated phosphorylation of metabolic enzymes.